Laboratory of Bioinformatics and Systems Biology

Lab_bioinf_syst_biol

Head: Krzysztof PAWŁOWSKI

Staff: Anna LENART (PhD student), Teresa SZCZEPIŃSKA (PhD student)

Research profile

Structure and function predictions for proteins important in human disease, in particular uncharacterised transmembrane proteins; Systems biology analysis of gene expression data; Evolutionary analysis of gene expression profiles.

Current research activities

  • Structure / function analysis and evolutionary history of CLCAs, a novel enzyme family;
  • Structure / function analysis of a novel family of putative transmembrane receptors;
  • Studying expression profiles of drug targets;
  • New methods for pathway analysis of gene expression data: development of the GSEA method (gene set enrichment analysis)

    Selected publications

    A widespread peroxiredoxin-like domain in tumor suppression- and progression-implicated proteins K. Pawłowski, A. Muszewska, A. Lenart, T. Szczepińska, A. Godzik, M. Grynberg BMC Genomics (2010), 11, 590

    An Approach to Prediction of the Haematopoietic Stem Cell Transplantation Outcome Using Human Leukocyte Antigen Mismatch Information Mapped on Protein Structure Data M.Z. Dudkiewicz, P .Malanowski, J. Czerwiński, K. Pawłowski Biology of Blood and Marrow Transplantation (2009), 15, 1014-1025

    Uncharacterised / hypothetical proteins in biomedical “omics” experiments: is novelty being swept under the carpet? K. Pawłowski Briefings in Functional Genomics and Proteomics (2008), 7, 283-90.

    TNF-α- induced self expression in human lung endothelial cells is inhibited by native and oxidized α1-antitrypsin D. Subramaniyam, R. Virtala, K. Pawłowski, I. Groth Clausen, S. Warkentin, T. Stevens, S. Janciauskiene The International Journal of Biochemistry & Cell Biology (2008), 40, 258-71.

    Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease S. Pierrou, P. Broberg, R.A. O’Donnell, K. Pawłowski, R. Virtala, E. Lindqvist, A. Richter, S.J. Wilson, G. Angco, S. Moller, H. Bergstrand, W. Koopmann, E. Wieslander, P.E. Stromstedt, S.T. Holgate, D.E. Davies, J. Lund, R. Djukanovic American Journal of Respiriratory and Critical Care Medicine (2007), 175, 577-86.

    Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels. K. Pawłowski, M. Lepisto, N. Meinander, U. Sivars, M. Varga, E. Wieslander Proteins (2006), 63, 424-439

    Surface map comparison. Studying function diversity of homologous proteins. K. Pawłowski and A. Godzik Journal of Molecular Biology (2001), 309, 793-806

    PAAD – a new protein domain associated with apoptosis, cancer and autoimmune diseases.
    K. Pawłowski, F. Pio, Z.-L. Chu, J.C. Reed and A. Godzik Trends in Biochemical Sciences (2001), 26, 85-87
Projects Conferences
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